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KMID : 1140120080130010026
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Cancer Prevention Research
2008 Volume.13 No. 1 p.26 ~ p.32
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The Cytotoxic Effects of the Viola mandshurica Extracts on HT-29 Human Colon Cancer Cells
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Jo Kyung-Jin
Park Eun-Ju
Lee Seung-Cheol
Park Hae-Ryong
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Abstract
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This study was performed to investigate the cytotoxic activity from Viola mandshurica (VM) extracts. Traditionally, VM has been used in the prevention and treatment of anti-inflammatory, diuretic. However, the cytotoxic activity of VM against cancer cells has not, until now, been elucidated. We found that the extracts of V. mandshurica (VME) have cytotoxic effects on HT-29 human colon cancer cells. As expected, VME inhibited growth of HT-29 cells in a dose-dependent manner as assessed by the MTT reduction assay, the LDH release assay, and colony formation assay. Interestingly, we also detected apoptotic bodies on Hoechst staining. These results indicate that VME contains bioactive materials with strong activity, and is a potential chemotherapeutic agent candidate against human colon cancer cells. (Cancer Prev Res 13, 26-32, 2008)
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KEYWORD
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Cytotoxicity, Viola mandshurica, HT-29 cells, Apoptosis, Bioactive materials
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